منابع مشابه
Cancer stem cells: therapeutic targets
Cancer stem cells (CSCs) have been identified as rare cellular populations in many cancers, including leukemia and solid tumors. This minor subpopulation of cancerous cells is immortal tumor-initiating cells which thought to be responsible for cancer initiation, progression, metastasis, recurrence and drug/radiation resistance. Low proliferative rate, high self-renewing capacity, differentiatio...
متن کاملcancer stem cells: therapeutic targets
cancer stem cells (cscs) have been identified as rare cellular populations in many cancers, including leukemia and solid tumors. this minor subpopulation of cancerous cells is immortal tumor-initiating cells which thought to be responsible for cancer initiation, progression, metastasis, recurrence and drug/radiation resistance. low proliferative rate, high self-renewing capacity, differentiatio...
متن کاملShigella impairs T lymphocyte dynamics in vivo.
The Gram-negative enteroinvasive bacterium Shigella flexneri is responsible for the endemic form of bacillary dysentery, an acute rectocolitis in humans. S. flexneri uses a type III secretion system to inject effector proteins into host cells, thus diverting cellular functions to its own benefit. Protective immunity to reinfection requires several rounds of infection to be elicited and is short...
متن کاملT-lymphocyte clones responsive to Shigella flexneri.
T lymphocytes from a patient with Shigella flexneri dysentery and postdysenteric reactive arthritis were cloned by limiting dilution with recombinant interleukin-2 and a strain of S. flexneri different from that which had infected her. Five of eight clones produced proliferated in response to the shigellae used to generate the clones. The response required irradiated syngeneic blood mononuclear...
متن کاملT-related bacteriophages isolated from Shigella sonnei.
The properties of three T-related phages-35, 55, and 3201-isolated from Shigella sonnei were studied. They were similar with respect to morphology of plaques, duration of the latent periods, lysis inhibition effect, and serological characteristics. These phages closely resembled the T-even phages. Phages 3201, 35, and 55 had the same host range and receptor specificity as phage T2.
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2011
ISSN: 1931-3128
DOI: 10.1016/j.chom.2011.04.003